Recombinant human TNFRSF27/EDA2R protein

EDA2R also known as Tumor necrosis factor receptor superfamily member 27 isoform 2, is a transmembrane protein in the TNF receptor superfamily. This protein itself is strongly associated with androgenetic alopecia (male hair loss) . It is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, it can associate with Fas and induce EDA-A2 dependent apoptosis. Recombinant human EDA2R protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

EDA2R, EDA-A2 receptor, EDAA2R, EDA-A2R, TNFRSF27, Tumor necrosis factor receptor superfamily member 27 isoform 2, XEDAR, X-linked ectodysplasin-A2 receptor

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

42.5 kDa (380aa)

Additionnal Information

EDA2R, TNFRSF27, XEDAR, Tumor necrosis factor receptor superfamily member 27 isoform 2, EDA2R, EDA-A2R, EDAA2R, TNFRSF27, XEDAR, ATGP3531-10 µg, ATGP3531-20 µg, ATGP3531-50 µg, ATGP3531-100 µg, ATGP3531-250 µg, ATGP3531-500 µg, ATGP3531-1 mg, ATGP3531-10, ATGP3531-20, ATGP3531-50, ATGP3531-100, ATGP3531-250, ATGP3531-500, ATGP3531-1

References & Citations

Brosh R., et al. (2010) FEBS Lett. 584:2473-2477; ; Redler S., et al. (2012) Br J Dermatol. 166:1314-1318

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol, 1mM DTT

Scientific Category

Apoptosis

NCBI Accession Number

NP_001229239

Uniprot Accession Number

Q9HAV5

Species

Human

N Terminal Sequence

Ala

AA Sequence

MDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA T