Recombinant human SCN3B protein

SCN3B, also known as sodium channel subunit beta-3, is an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. It was detected in brain, heart, kidney, lung, pancreas and skeletal muscle. It is expressed in adult mammalian skeletal muscle and can functionally couple to the skeletal muscle alpha subunit, SkM1. It associates with neurofascin through their extracellular immunoglobulin-like domain. Recombinant human SCN3B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Sodium channel subunit beta-3, SCN3B, ATFB16, BRGDA7, HSA243396, SCNB3

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

16.8 kDa (146aa)

Additionnal Information

SCN3B, Sodium channel subunit beta-3, SCN3B, ATFB16, BRGDA7, HSA243396, SCNB3, ATGP3521-10 µg, ATGP3521-20 µg, ATGP3521-50 µg, ATGP3521-100 µg, ATGP3521-250 µg, ATGP3521-500 µg, ATGP3521-1 mg, ATGP3521-10, ATGP3521-20, ATGP3521-50, ATGP3521-100, ATGP3521-250, ATGP3521-500, ATGP3521-1

References & Citations

Stevens EB., et al. (2001) Pflugers Arch. 441:481-488.; ; Ratcliffe CF., et al. (2001) J Cell Biol. 154:427-434.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_060870

Uniprot Accession Number

Q9NY72

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPFPVCVEV PSETEAVQGN PMKLRCISCM KREEVEATTV VEWFYRPEGG KDFLIYEYRN GHQEVESPFQ GRLQWNGSKD LQDVSITVLN VTLNDSGLYT CNVSREFEFE AHRPFVKTTR LIPLRVTEEA GEDFTSVVSE HHHHHH