Recombinant human SCN3B protein
SCN3B, also known as sodium channel subunit beta-3, is an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. It was detected in brain, heart, kidney, lung, pancreas and skeletal muscle. It is expressed in adult mammalian skeletal muscle and can functionally couple to the skeletal muscle alpha subunit, SkM1. It associates with neurofascin through their extracellular immunoglobulin-like domain. Recombinant human SCN3B, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Sodium channel subunit beta-3, SCN3B, ATFB16, BRGDA7, HSA243396, SCNB3
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
16.8 kDa (146aa)
Additionnal Information
References & Citations
Stevens EB., et al. (2001) Pflugers Arch. 441:481-488.; ; Ratcliffe CF., et al. (2001) J Cell Biol. 154:427-434.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_060870
Uniprot Accession Number
Q9NY72
Species
Human
N Terminal Sequence
Ala
AA Sequence
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