Recombinant human FOLR1 protein

FOLR1, as known as folate receptor alpha, is a member of the folate receptor family. This protein meditates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide ad methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. Also, mature form is an N-glycosylated protein that is anchored to the cell surface by a GPI linkages. Recombinant human FOLR1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Folate receptor alpha, FOLR1, FBP, FOLR

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

25.6 kDa (218aa)

Additionnal Information

FOLR1, Folate receptor alpha, FOLR1, FBP, FOLR, ATGP3518-10 µg, ATGP3518-20 µg, ATGP3518-50 µg, ATGP3518-100 µg, ATGP3518-250 µg, ATGP3518-500 µg, ATGP3518-1 mg, ATGP3518-10, ATGP3518-20, ATGP3518-50, ATGP3518-100, ATGP3518-250, ATGP3518-500, ATGP3518-1

References & Citations

Hansen MJ., et al, (2015) Inflamm. Res. 64:697-706.; ; Ab O., et al, (2015) Mol. Cancer Ther. 14:1605-1613.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_000793.1

Uniprot Accession Number

P15328

Species

Human

N Terminal Sequence

Ala

AA Sequence

IAWARTE LLNVCMNAKH HKEKPGPEDK LHEQCRPWRK NACCSTNTSQ EAHKDVSYLY RFNWNHCGEM APACKRHFIQ DTCLYECSPN LGPWIQQVDQ SWRKERVLNV PLCKEDCEQW WEDCRTSYTC KSNWHKGWNW TSGFNKCAVG AACQPFHFYF PTPTVLCNEI WTHSYKVSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAAA MS