Recombinant mouse Histone Deacetylase 8/HDAC8 protein
Hdac8, also known as histone deacetylase 8 isoform 1, is a member of the class I Histone Deacetylases. Its specific inhibition reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. It expressed in the renal epithelial cells of the mouse kidney. Its activity contributes to renal protection and functional recovery and is required for renal regeneration after AKI. Recombinant mouse Hdac8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Histone deacetylase 8 isoform 1, Hdac8, 2610007D20Rik, HD8, Protein deacetylase HDAC8, Protein decrotonylase HDAC8
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
42.5 kDa (383aa)
Additionnal Information
References & Citations
Li S., et al. (2015) J Biol Chem. 290:2368-2378.; ; Tang J., et al. (2014) Am J Physiol Renal Physiol. 307:F303-316.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_081658
Uniprot Accession Number
Q8VH37
Species
Mouse
N Terminal Sequence
Met1
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