Recombinant mouse CREG/CREG1 protein

Creg1, also known as Cellular repressor of E1A-stimulated genes1, was antagonizes transcriptional activation and cellular transformation by E1A. This protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. Creg1 increases EC filopodia formation and vascular assembly via ILK-Cdc42 activation and promotes neovascularization, which might be a therapeutic target for ischemic injury. Recombinant mouse Creg1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Cellular repressor of E1A-stimulated genes1, AA755314, Creg

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Purity

> 95% by SDS-PAGE

Molecular Weight

24 kDa (213aa)

Additionnal Information

Creg1, Cellular repressor of E1A-stimulated genes1, AA755314, Creg, ATGP3512-10 µg, ATGP3512-20 µg, ATGP3512-50 µg, ATGP3512-100 µg, ATGP3512-250 µg, ATGP3512-500 µg, ATGP3512-1 mg, ATGP3512-10, ATGP3512-20, ATGP3512-50, ATGP3512-100, ATGP3512-250, ATGP3512-500, ATGP3512-1

References & Citations

Wang, N., et al. (2011) Atherosclerosis. 218 (2) :543-51 ; ; Yan C., et al. (2014) Front Biosci. 19:1151-61.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_035934

Uniprot Accession Number

O88668

Species

Mouse

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMRGGRDH GDWDVDRRLP PLPPREDGPR VARFVTHVSD WGSLATISTI KEVRGWPFAD IISISDGPPG EGTGEPYMYL SPLQQAVSDL QENPEATLTM SLAQTVYCRN HGFDPQSPLC VHIMMSGTVT KVNKTEEDYA RDSLFVRHPE MKHWPSSHNW FFAKLKISRI WVLDYFGGPK VVTPEEYFNV TLQ