Recombinant mouse Lactadherin/MFGE8 protein
Mfge8, also known as Milk fat globule-EGF factor 8 protein, is pleiotropic secreted glycoprotein that promotes mammary gland morphogenesis, angiogenesis, and tumor progression. It also plays an important role in tissue homeostasis and the prevention of inflammation. It functions as a bridge between phosphatidylserine on apoptotic cells and Integrin alpha V beta 3 on phagocytes, leading to the clearance of apoptotic debris. Recombinant mouse Mfge8 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Milk fat globule EGF and factor V/VIII domain containing, EGF/factor VIII, Lactadherin, MFG-E8, Mfgm, SED1
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
46kDa (413aa)
Additionnal Information
References & Citations
Oba J., et al. (2011) Br J Dermatol. 165: 506-512.; ; Liu F., et al. (2014) Stroke. 45: 3691-3697.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Apoptosis
NCBI Accession Number
NP_001038954
Uniprot Accession Number
Q3TDU5
Species
Mouse
N Terminal Sequence
Ala
AA Sequence
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