Recombinant human Kallikrein 5/KLK5 protein
KLK5, also known as kallikrein-5, is one of the newly identified members of the kallikrein gene family, which is a subgroup of the serine protease enzyme family. It is highly expressed in skin, mammary gland and testis. KLK5 has been suggested to regulate cell shedding (desquamation) in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. It is proposed that KLK5 regulates this process since it is able to self-activate in addition to activating KLK7 and KLK14. Recombinant human KLK5, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Kallikrein-5, KLK5, KLKL2, SCTE, Kallikrein related peptidase 5, Kallikrein-like protein 2, Stratum corneum tryptic enzyme
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
26.2 kDa (236aa)
Additionnal Information
References & Citations
Kim H., et al. (2001) Br J Cancer. 84:643-650.; ; Pampalakis G., et al. (2014) Oncotarget. 5:2390-2403.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001070960.1
Uniprot Accession Number
Q9Y337
Species
Human
N Terminal Sequence
Ala
AA Sequence
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