Recombinant human ULBP-2 protein
ULBP2, also known as NKG2D ligand 2, is a member of a family of cell-surface proteins that function as ligands for human NKG2D. Carithromycin induces ULBP2 expression and reduces the amount of sULBP2, by possibly inhibiting the activity of the potent ULBP2-shedding enzyme ADAM17. Because these changes in ULBP2 and sULBP2 levels could activate NKT cells, this finding might indicate a novel mechanism by which clarithromycin improves the clearance of P. aeruginosa in chronic respiratory diseases. It is a useful serum biomarker for pancreatic cancer detection. Recombinant human ULBP2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
UL16 binding protein 2, ALCAN-alpha, NKG2D ligand 2, N2DL-2, NKG2DL2, Retinoic acid early transcript 1H, RAET1H, N2DL2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
22.7 kDa (200aa)
Additionnal Information
References & Citations
Okada K., et al. (2015) Yonago Acta Med. 58:31-38.; ; Chang YT., et al. (2011) PLoS One. 6:e20029.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_079493
Uniprot Accession Number
Q9BZM5
Species
Human
N Terminal Sequence
Ala
AA Sequence
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