Recombinant human ULBP-2 protein

ULBP2, also known as NKG2D ligand 2, is a member of a family of cell-surface proteins that function as ligands for human NKG2D. Carithromycin induces ULBP2 expression and reduces the amount of sULBP2, by possibly inhibiting the activity of the potent ULBP2-shedding enzyme ADAM17. Because these changes in ULBP2 and sULBP2 levels could activate NKT cells, this finding might indicate a novel mechanism by which clarithromycin improves the clearance of P. aeruginosa in chronic respiratory diseases. It is a useful serum biomarker for pancreatic cancer detection. Recombinant human ULBP2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

UL16 binding protein 2, ALCAN-alpha, NKG2D ligand 2, N2DL-2, NKG2DL2, Retinoic acid early transcript 1H, RAET1H, N2DL2

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

22.7 kDa (200aa)

Additionnal Information

ULBP2, NKG2D ligand 2, ULBP2, ALCAN-alpha, N2DL2, NKG2DL2, RAET1H, ATGP3491-10 µg, ATGP3491-20 µg, ATGP3491-50 µg, ATGP3491-100 µg, ATGP3491-250 µg, ATGP3491-500 µg, ATGP3491-1 mg, ATGP3491-10, ATGP3491-20, ATGP3491-50, ATGP3491-100, ATGP3491-250, ATGP3491-500, ATGP3491-1

References & Citations

Okada K., et al. (2015) Yonago Acta Med. 58:31-38.; ; Chang YT., et al. (2011) PLoS One. 6:e20029.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_079493

Uniprot Accession Number

Q9BZM5

Species

Human

N Terminal Sequence

Ala

AA Sequence

GRADPHS LCYDITVIPK FRPGPRWCAV QGQVDEKTFL HYDCGNKTVT PVSPLGKKLN VTTAWKAQNP VLREVVDILT EQLRDIQLEN YTPKEPLTLQ ARMSCEQKAE GHSSGSWQFS FDGQIFLLFD SEKRMWTTVH PGARKMKEKW ENDKVVAMSF HYFSMGDCIG WLEDFLMGMD STLEPSAGAP LAMS