Recombinant mouse FcRn/FCGRT protein

Fcgrt, as known as IgG receptor FcRn large subunit p51, is a transmembrane glycoprotein with structural homology to MHC class 1 proteins. This protein is widely expressed in endothelial and epithelial cells and plays an important rloe in IgG homeostasis. Also, it is expessed in neutrophils and myeloid antigen presenting cells. It can enhance IgG-meditated phagocytosis and antigen presentation by heses cells, but it promotes the degradation of opsonizing IgG rather than returning it to the circulation. Recombinant mouse Fcgrt, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

IgG receptor FcRn large subunit p51, Fcgrt, FcRn, Fc gamma receptor and transporter, FcgammaRn, Transmembrane alpha chain of the neonatal receptor, Neonatal Fc receptor, FCRN alpha-chai

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

32.1 kDa (285aa)

Additionnal Information

IgG receptor FcRn large subunit p51, Fcgrt, FcRn, Fc gamma receptor and transporter, FcgammaRn, Transmembrane alpha chain of the neonatal receptor, Neonatal Fc receptor, FCRN alpha-chain, FCRN alpha chain, ATGP3485-10 µg, ATGP3485-20 µg, ATGP3485-50 µg, ATGP3485-100 µg, ATGP3485-250 µg, ATGP3485-500 µg, ATGP3485-1 mg, ATGP3485-010, ATGP3485-020, ATGP3485-050, ATGP3485-100, ATGP3485-250, ATGP3485-500, ATGP3485-01M

References & Citations

Baker K., et al, (2013) Immunity 39:1095-1107.; ; Paveglio S., et al, (2012) Clin. Exp. Allergy 42:1791-1800.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_034319.2

Uniprot Accession Number

Q61559

Species

Mouse

N Terminal Sequence

Ala

AA Sequence

SETRPPL MYHLTAVSNP STGLPSFWAT GWLGPQQYLT YNSLRQEADP CGAWMWENQV SWYWEKETTD LKSKEQLFLE ALKTLEKILN GTYTLQGLLG CELASDNSSV PTAVFALNGE EFMKFNPRIG NWTGEWPETE IVANLWMKQP DAARKESEFL LNSCPERLLG HLERGRRNLE WKEPPSMRLK ARPGNSGSSV LTCAAFSFYP PELKFRFLRN GLASGSGNCS TGPNGDGSFH AWSLLEVKRG DEHHYQCQVE HEGLAQPLTV DLDSSARSS