Recombinant human NTB-A/SLAMF6 protein
SLAMF6, also known as SLAM family member 6 isoform 1, belongs to the SLAM family of immune cell receptors. It is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. This protein is expressed on NK-, T-, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs) . It may function as a coreceptor in the process of NK cell activation. Recombinant human SLAMF6 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
SLAMF family member 6 isoform 1, SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
24.1 kDa (214aa)
Additionnal Information
References & Citations
Aversa G. et al., (1997) Immunol Cell Biol. 75:202-205.; ; Valdez PA. et al., (2004) J. Biol. Chem. 279:18662-18669.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001171643
Uniprot Accession Number
Q96DU3
Species
Human
N Terminal Sequence
Ala
AA Sequence
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