Recombinant human NTB-A/SLAMF6 protein

SLAMF6, also known as SLAM family member 6 isoform 1, belongs to the SLAM family of immune cell receptors. It is a novel receptor on T cells that, when engaged, potentiates T cell expansion in a CD28-independent manner. This protein is expressed on NK-, T-, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs) . It may function as a coreceptor in the process of NK cell activation. Recombinant human SLAMF6 protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

SLAMF family member 6 isoform 1, SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

24.1 kDa (214aa)

Additionnal Information

NTB-A, SLAMF6, SLAMF family member 6 isoform 1, SLAMF6, CD352, KALI, KALIb, Ly108, NTB-A, NTBA, SF2000, ATGP3483-10 µg, ATGP3483-20 µg, ATGP3483-50 µg, ATGP3483-100 µg, ATGP3483-250 µg, ATGP3483-500 µg, ATGP3483-1 mg, ATGP3483-10, ATGP3483-20, ATGP3483-50, ATGP3483-100, ATGP3483-250, ATGP3483-500, ATGP3483-1

References & Citations

Aversa G. et al., (1997) Immunol Cell Biol. 75:202-205.; ; Valdez PA. et al., (2004) J. Biol. Chem. 279:18662-18669.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001171643

Uniprot Accession Number

Q96DU3

Species

Human

N Terminal Sequence

Ala

AA Sequence

ADPQSSLTPL MVNGILGESV TLPLEFPAGE KVNFITWLFN ETSLAFIVPH ETKSPEIHVT NPKQGKRLNF TQSYSLQLSN LKMEDTGSYR AQISTKTSAK LSSYTLRILR QLRNIQVTNH SQLFQNMTCE LHLTCSVEDA DDNVSFRWEA LGNTLSSQPN LTVSWDPRIS SEQDYTCIAE NAVSNLSFSV SAQKLCEDVK IQYTDTKMHH HHHH