Recombinant human DNAM-1/CD226 protein
CD226, also known as CD226 antigen isoform, is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set. It is an activating receptor expressed on NK cells and T cells and plays an important role in cytotoxicity of these cells against target cells. It mediates platelet and megakaryocytic cell adhesion to vascular endothelial cells. Recombinant human CD226, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
CD226 antigen isoform, CD226, DNAM-1, DNAM1, PTA1, TLiSA1
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
53.2 kDa (471aa)
Additionnal Information
References & Citations
Vo AV., et al. (2016) Mol Immunol. 69:70-76.; ; Kojima H., et al. (2003) J Biol Chem. 278:36748-36753.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_006557
Uniprot Accession Number
Q15762
Species
Human
N Terminal Sequence
Ala
AA Sequence
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