Recombinant mouse IL-17RB protein
Il17rb, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17 (A) or IL17C. It has been shown to mediate the activation of NF- kB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immune regulatory activity of this receptor. Recombinant mouse Il17rb, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
57.1 kDa (511aa)
Additionnal Information
References & Citations
Rickel EA. et al., (2008) J. Immunol. 181 (6) :4299-4310.; ; Aggarwal, S. et al., (2002) J. Leukoc. Biol. 71:1-8.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_062529
Uniprot Accession Number
Q9JIP3
Species
Mouse
N Terminal Sequence
Ala
AA Sequence
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