Recombinant mouse IL-17RB protein

Il17rb, also known as Interleukin-17 receptor B, is a cytokine receptor. This receptor specifically binds to IL17B and IL17E (IL25), but does not bind to IL17 (A) or IL17C. It has been shown to mediate the activation of NF- kB and the production of IL8 induced by IL17E. It was found to be significantly up-regulated during intestinal inflammation, which suggested the immune regulatory activity of this receptor. Recombinant mouse Il17rb, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin-17 receptor B, Il17rb, Evi27, IL-17ER, IL-17Rh1, Il17br, IL17RH1, IL-17 receptor B, IL-17 receptor homolog 1, Interleukin-17B receptor, IL-17B receptor

Expression System

Baculovirus

Antigen Species

Mouse

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

57.1 kDa (511aa)

Additionnal Information

Interleukin-17B receptor, Interleukin-17 receptor B, Interleukin 17B receptor, Interleukin 17 receptor B, Interleukin17B receptor, Interleukin17 receptor B, IL-17Rh1, IL17RH1, IL 17RH1, Il17rb, IL-17ER, Il17br, IL-17B receptor, IL-17 receptor homolog 1, IL-17 receptor B, IL17B receptor, IL17 receptor homolog 1, IL17 receptor B, IL 17B receptor, IL 17 receptor homolog 1, IL 17 receptor B, IL17 RB, IL 17 RB, Evi27, ATGP3472-10 µg, ATGP3472-20 µg, ATGP3472-50 µg, ATGP3472-100 µg, ATGP3472-250 µg, ATGP3472-500 µg, ATGP3472-1 mg, ATGP3472-010, ATGP3472-020, ATGP3472-050, ATGP3472-100, ATGP3472-250, ATGP3472-500, ATGP3472-01M

References & Citations

Rickel EA. et al., (2008) J. Immunol. 181 (6) :4299-4310.; ; Aggarwal, S. et al., (2002) J. Leukoc. Biol. 71:1-8.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_062529

Uniprot Accession Number

Q9JIP3

Species

Mouse

N Terminal Sequence

Ala

AA Sequence

ADPREPTIQC GSETGPSPEW MVQHTLTPGD LRDLQVELVK TSVAAEEFSI LMNISWILRA DASIRLLKAT KICVSGKNNM NSYSCVRCNY TEAFQSQTRP SGGKWTFSYV GFPVELSTLY LISAHNIPNA NMNEDSPSLS VNFTSPGCLN HVMKYKKQCT EAGSLWDPDI TACKKNEKMV EVNFTTNPLG NRYTILIQRD TTLGFSRVLE NKLMRTSVAI PVTEESEGAV VQLTPYLHTC GNDCIRREGT VVLCSETSAP IPPDDNRRML GGVEPKSCDK THTCPPCPAP ELLGGPSVFL FPPKPKDTLM ISRTPEVTCV VVDVSHEDPE VKFNWYVDGV EVHNAKTKPR EEQYNSTYRV VSVLTVLHQD WLNGKEYKCK VSNKALPAPI EKTISKAKGQ PREPQVYTLP PSRDELTKNQ VSLTCLVKGF YPSDIAVEWE SNGQPENNYK TTPPVLDSDG SFFLYSKLTV DKSRWQQGNV FSCSVMHEAL HNHYTQKSLS LSPGKHHHHH H