Recombinant human sFRP-4/SFRP4 protein
SFRP4, also known as secreted frizzled-related protein4, is a family of vertebrate proteins which contain homology to the ligand-binding domain of the Frizzled family of transmembrane receptors. It is expressed in brain, kidney, lung, ovary, prostate, mammary gland and endometrium. This protein act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. It is able to bind Wnt proteins and Frizzled receptors in the extracellular compartment. Recombinant human SFRP4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Secreted frizzled-related protein 4, SFRP4, FRP-4, FRPHE, PYL, sFRP-4, Human endometrium Frizzled protein, FRZB-2
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
38.9 kDa (337aa)
Additionnal Information
References & Citations
Jones SE., et al. (2002) Bioessays 24:811-820.; ; Berndt T., et al. (2003) J Clin Invest. 112:785-794.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Stem cell
NCBI Accession Number
NP_003005
Uniprot Accession Number
Q6FHJ7
Species
Human
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
