Recombinant mouse NKp46/NCR1 protein

Ncr1, as known as natural cytotoxicity triggering receptor 1, is a natural killer cell p46-related protein. This protein, along with NKp30 and NKp44, are activiting receptors that belongs to the natural cytotoxicity receptor family. These receptors are expressed by NK cells in the peripheral blood and spleen expresses NKp46 in both resting and activated states. Also, it may contribute to the increased efficiency of activated NK cells to meditate tumor cell lysis. Recombinant mouse Ncr1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

NKp46 Extracellular Ig-like domain, NK-p46, NK cell-activating receptor, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen

Expression System

Baculovirus

Antigen Species

Mouse

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

54.4 kDa (481aa)

Additionnal Information

NKp46 Extracellular Ig-like domain, NKp-46 Extracellular Ig-like domain, NKp46, NK p46, NK-p46, NK cell-activating receptor, NCR-1, NCR 1, NCR1, NCR, Natural killer cell p46-related protein, Natural cytotoxicity triggering receptor 1 isoform a, Natural cytotoxicity triggering receptor 1, Lymphocyte antigen 94 homolog, Ly96, LY94, hNKp46, CD335 antigen, ATGP3464-10 µg, ATGP3464-20 µg, ATGP3464-50 µg, ATGP3464-100 µg, ATGP3464-250 µg, ATGP3464-500 µg, ATGP3464-1 mg, ATGP3464-010, ATGP3464-020, ATGP3464-050, ATGP3464-100, ATGP3464-250, ATGP3464-500, ATGP3464-01M

References & Citations

Sheppard S., et al, (2013) Blood 121:5025-5033.; ; Walzer T., et al, (2007) Proc. Natl. Acad. Sci. U.S.A. 104:3384-3389.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_034876.1

Uniprot Accession Number

Q8C567

Species

Mouse

N Terminal Sequence

Ala

AA Sequence

QRINTEK ETLPKPIIWA KPSIMVTNGN SVNIWCQGAQ SASEYQLYFE GSFFALERPK PSRSMNKVRF FISQMTSHTA GIYTCFYQSG ELWSKSSNPL KLVVTGLYDT PNLWVYPRPE VTLGENVTFF CQLKTATSKF FLLKERGSNH IQNKYGNIQA EFPMGPVTRA HRGTYRCFGS YNDYAWSFPS EPVTLLITGG VENSSLAPTD PTSSLDYWEF DLSTNESGLQ KDSAFWDHTT QN