Recombinant human TROP-2 protein

TACSTD2, also known as tumor-associated calcium signal transducer 2, is an identified cell surface glycoprotein highly expressed by human carcinomas. It is detected in normal kidney, lung, ovary and testis, similarly to the human gene. It is undetectable in undifferentiated spindle cell carcinomas, this suggests a preferential expression at early stages of tumor progression. Its inhibition suppresses the proliferation and invasion of laryngeal carcinoma cells via the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway. Recombinant human TACSTD2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tumor-associated calcium signal transducer 2, TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

28.6 kDa (253aa)

Additionnal Information

TROP2, Tumor-associated calcium signal transducer 2 , TACSTD2, EGP-1, EGP1, GA733-1, GA7331, GP50, M1S1, TROP2, ATGP3463-10 µg, ATGP3463-20 µg, ATGP3463-50 µg, ATGP3463-100 µg, ATGP3463-250 µg, ATGP3463-500 µg, ATGP3463-1 mg, ATGP3463-10, ATGP3463-20, ATGP3463-50, ATGP3463-100, ATGP3463-250, ATGP3463-500, ATGP3463-1

References & Citations

Wang XD., et al. (2015) Mol Med Rep. 12:865-870.; ; Ripani E., et al. (1998) Int J Cancer. 76:671-676.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_002344.2

Uniprot Accession Number

P09758

Species

Human

N Terminal Sequence

Ala

AA Sequence

QDNCTCP TNKMTVCSPD GPGGRCQCRA LGSGMAVDCS TLTSKCLLLK ARMSAPKNAR TLVRPSEHAL VDNDGLYDPD CDPEGRFKAR QCNQTSVCWC VNSVGVRRTD KGDLSLRCDE LVRTHHILID LRHRPTAGAF NHSDLDAELR RLFRERYRLH PKFVAAVHYE QPTIQIELRQ NTSQKAAGDV DIGDAAYYFE RDIKGESLFQ GRGGLDLRVR GEPLQVERTL IYYLDEIPPK FSMKRLT