Recombinant human IL-18BP protein
IL18BP, as known as interleukin-18-binding protein isoform, is a secreted glycoprotein. It belongs to the interleukin 1 receptor family. This protein functions as an IL18 antagonist by binding to IL18 and blocking its biological activity. Also, it is essential for IL18 meditated signal transduction. The expression of IL18BP is markedly upregulated by IFN-gamma, suggesting that IL18 activity is modulated by a negative feedback mechanism meditated by IL18BP. Recombinant human IL18BP, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Interleukin-18-binding protein, IL18BPa, Interleukin-18-binding protein isoform, IL18BP, Tadekinig-alfa
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
44.9 kDa (406aa)
Additionnal Information
References & Citations
Wang YB., et al. (2011) J. Int. Med. Res. 39:2201-2208.; ; Palladino I., et al, (2012) J Neuroinflammation 9:206.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001138529
Uniprot Accession Number
O95998
Species
Human
N Terminal Sequence
Ala
AA Sequence
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