Recombinant human IL-18BP protein

IL18BP, as known as interleukin-18-binding protein isoform, is a secreted glycoprotein. It belongs to the interleukin 1 receptor family. This protein functions as an IL18 antagonist by binding to IL18 and blocking its biological activity. Also, it is essential for IL18 meditated signal transduction. The expression of IL18BP is markedly upregulated by IFN-gamma, suggesting that IL18 activity is modulated by a negative feedback mechanism meditated by IL18BP. Recombinant human IL18BP, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin-18-binding protein, IL18BPa, Interleukin-18-binding protein isoform, IL18BP, Tadekinig-alfa

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

44.9 kDa (406aa)

Additionnal Information

Interleukin-18 binding protein, Interleukin 18 binding protein, Interleukin-18-binding protein, IL18BPa, Interleukin 18 binding protein isoform, Interleukin-18-binding protein isoform, Interleukin18 binding protein isoform, IL18BP, Tadekinig-alfa, Tadekinig alfa, ATGP3459-10 µg, ATGP3459-20 µg, ATGP3459-50 µg, ATGP3459-100 µg, ATGP3459-250 µg, ATGP3459-500 µg, ATGP3459-1 mg, ATGP3459-010, ATGP3459-020, ATGP3459-050, ATGP3459-100, ATGP3459-250, ATGP3459-500, ATGP3459-01M

References & Citations

Wang YB., et al. (2011) J. Int. Med. Res. 39:2201-2208.; ; Palladino I., et al, (2012) J Neuroinflammation 9:206.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_001138529

Uniprot Accession Number

O95998

Species

Human

N Terminal Sequence

Ala

AA Sequence

TPVSQTT TAATASVRST KDPCPSQPPV FPAAKQCPAL EVTWPEVEVP LNGTLSLSCV ACSRFPNFSI LYWLGNGSFI EHLPGRLWEG STSRERGSTG TQLCKALVLE QLTPALHSTN FSCVLVDPEQ VVQRHVVLAQ LWAGLRATLP PTQEALPSSH SSPQQQG