Recombinant mouse CD200R1 protein
Cd200r1, also known cell surface glycoprotein CD200 receptor 1, is an isoform of CD200 receptors which is expressed on cells of the myeloid lineage. Its inhibitory signaling pathway has been implicated in playing a prominent role in limiting inflammation in a wide range of inflammatory diseases. Its signaling inhibits the expression of proinflammatory molecules including tumor necrosis factor, interferons, and inducible nitric oxide synthase in response to selected stimuli. Recombinant mouse Cd200r1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human CD200 (CAT# ATGP3964) is coated at 1 µg/mL (100 ul/well) can bind Human CD200 R1. The ED50 range ≤ 1 µg/mL.
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Mouse
Tag
HIgG-His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Mouse CD200 (CAT# ATGP3964) . The ED50 range ≤ 1 µg/mL.
Molecular Weight
50.4 kDa (455aa)
Additionnal Information
References & Citations
Vaine CA., et al. (2014) Adv Immunol. 121:191-211.; ; Horie S., et al. (2013) Sci Rep. 3:3072.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_067300
Uniprot Accession Number
Q9ES57
Species
Mouse
N Terminal Sequence
Ala
AA Sequence
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