Recombinant human MST2/STK3 protein

STK3, also known as serine/threonine-protein kinase 3, is a mammalian Ste20-related protein kinases most closely related to Drosophila Hippo, a major regulator of cell proliferation and survival during development. It is a serine/threonine kinase that functions early in a pheromone responsive signal transduction cascade in yeast. It activates the human large tumor suppressor kinase Lats1. It modulates stress-induced cardiac hypertrophy. Recombinant human STK3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Serine/threonine-protein kinase 3, STK3, KRS1, MST2

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

37.6 kDa (331aa)

Additionnal Information

MST2, STK3, Serine/threonine-protein kinase 3, STK3, KRS1, MST2, ATGP3452-10 µg, ATGP3452-20 µg, ATGP3452-50 µg, ATGP3452-100 µg, ATGP3452-250 µg, ATGP3452-500 µg, ATGP3452-1 mg, ATGP3452-10, ATGP3452-20, ATGP3452-50, ATGP3452-100, ATGP3452-250, ATGP3452-500, ATGP3452-1

References & Citations

Chan EH., et al. (2005) Oncogene. 24:2076-2086.; ; Taylor LK., et al. (1996) Proc Natl Acad Sci U S A. 93:10099-10104.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

NP_006272

Uniprot Accession Number

Q13188

Species

Human

N Terminal Sequence

Ala

AA Sequence

MEQPPAP KSKLKKLSED SLTKQPEEVF DVLEKLGEGS YGSVFKAIHK ESGQVVAIKQ VPVESDLQEI IKEISIMQQC DSPYVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT LIEDEIATIL KSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITSIEMAEG KPPYADIHPM RAIFMIPTNP PPTFRKPELW SDDFTDFVKK CLVKNPEQRA TATQLLQHPF IKNAKPVSIL RDLITEAMEI KAKRHEEQQR ELEEEEENSD EDELD