Recombinant human CD46 protein
CD46, also known as membrane cofactor protein isoform 14, is a type 1 membrane protein that plays an important inhibitory role in the complement system. It is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome, a disease characterized by uncontrolled complement activation. Recombinant human CD46, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Membrane cofactor protein isoform 14, CD46, AHUS2, MCP, MIC10, TLX, TRA2.10
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
32.5 kDa (288aa)
Additionnal Information
References & Citations
Lublin DM., et al. (1988) J Exp Med. 168:181-194.; ; Maga TK., et al. (2010) Hum. Mutat. 31:E1445-14460.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_758860
Uniprot Accession Number
P15529
Species
Human
N Terminal Sequence
Ala
AA Sequence
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