Recombinant human NOGO Receptor/RTN4R protein
RTN4R, also known as reticulon-4 receptor, is a glycosylphosphoinositol (GPI) -anchored protein that belongs to the Nogo recptor family including three members. It is expressed predominantly in neurons and their axons in the central nervous systems (CNS) . It may be proposed as a potential drug target for treatment of various neurological conditions such as spinal cord injury, CNS lesions, peripheral nerve injury, stroke and Alzheimer's disease (AD) . It may play a role in regulating the function of the gap junctions. Recombinant human RTN4R, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Reticulon-4 receptor, RTN4R, NGR, NOGOR, Nogo-66 receptor
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
46.3 kDa (429aa)
Additionnal Information
References & Citations
Tong S., et al. (2013) Oncol Rep. 30:2171-2178.; ; Wang X., et al. (2012) Exp Neurol. 237:55-69.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Neuroscience
NCBI Accession Number
NP_075380.1
Uniprot Accession Number
Q9BZR6
Species
Human
N Terminal Sequence
Cys27
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