Recombinant human FGF receptor 4/FGFR4 protein

FGFR4, as known as fibroblast growth factor receptor 4 isoform 1, is a glycosylated transmembrane receptor tyrosine kinase. This protein is widely expressed during embryonic development and in adult liver, kidney, and lung. Also, it is associates with beta-Klotho and sulfated glycosaminoglycans, and these interactions increase the affinity of FGFR4 for its ligands as well as its signaling capacity. This receptor signaling is additionally required for skeletal muscle development in limbs. Recombinant human FGFR4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Fibroblast growth factor receptor 4, FGFR-4, CD334, JTK2, TKF

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

39.5 kDa (356aa)

Additionnal Information

FGF R4, Fibroblast growth factor receptor 4 isoform 1, FGFR4, CD334, JTK2, TKF, CD 334, CD334 antigen, fc13h 10, fc13h10, Fgfr 4, FGFR-4, Fgfr4, FGFR4_HUMAN, Fibroblast growth factor receptor 4, Hydroxyaryl protein kinase, JTK 2, JTK2, MGC20292, Protein tyrosine kinase, TKF, Tyrosine kinase related to fibroblast growth factor receptor, Tyrosylprotein kinase, ATGP3423-10 µg, ATGP3423-20 µg, ATGP3423-50 µg, ATGP3423-100 µg, ATGP3423-250 µg, ATGP3423-500 µg, ATGP3423-1 mg, ATGP3423-10, ATGP3423-20, ATGP3423-50, ATGP3423-100, ATGP3423-250, ATGP3423-500, ATGP3423-1

References & Citations

Liu R., et al. (2013) Cancer Res. 73:5926-5935.; ; Shen YY., et al. (2013) World J. Gastroenterol. 19:4568-4575.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Cardiovascular

NCBI Accession Number

NP_002002

Uniprot Accession Number

P22455

Species

Human

N Terminal Sequence

Leu22

AA Sequence

LEASEEVELE PCLAPSLEQQ EQELTVALGQ PVRLCCGRAE RGGHWYKEGS RLAPAGRVRG WRGRLEIASF LPEDAGRYLC LARGSMIVLQ NLTLITGDSL TSSNDDEDPK SHRDPSNRHS YPQQAPYWTH PQRMEKKLHA VPAGNTVKFR CPAAGNPTPT IRWLKDGQAF HGENRIGGIR LRHQHWSLVM ESVVPSDRGT YTCLVENAVG SIRYNYLLDV LERSPHRPIL QAGLPANTTA VVGSDVELLC KVYSDAQPHI QWLKHIVING SSFGADGFPY VQVLKTADIN SSEVEVLYLR NVSAEDAGEY TCLAGNSIGL SYQSAWLTVL PEEDPTWTAA APEARYTDLE HHHHHH