Recombinant human LTA/TNF-beta protein
LTA, also known as lymphotoxin alpha and tumor necrosis factor beta, belongs to the tumor necrosis factor family. It is highly inducible, secreted, and forms heterotrimers with lymphotoxin beta which anchor lymphotoxin alpha to the cell surface. It is expressed by activated naive CD4 cells, unpolarized IL2 secreting effectors, and Th1 effectors and mediates a large variety of inflammatory, immunostimulatory, and antiviral responses. Recombinant human LTA, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Product Specifications
Specifications
Human LTA/TNF-beta induces cell cytotoxicity in the L-929 mouse fibroblast cells in the presence of the metabolic inhibitor actinomycin D.
Product Name Alternative
Lymphotoxin-alpha, LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, TNFB, TNFSF1, TNF superfamily, member 1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Bioactivity
Molecular Weight
19.7 kDa (180aa)
Additionnal Information
References & Citations
Messer G., et al. (1991) J Exp Med. 173:209-219.; ; Gramaglia I., et al. (1999) J Immunol 162:1333-1338
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001153212
Uniprot Accession Number
P01374
Species
Human
N Terminal Sequence
Ala
AA Sequence
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