Recombinant mouse EphB4 protein

Ephb4, also known as ephrin type-B receptor 4 isoform b, is a member of the Eph receptor tyrosine kinase family shown to act in neuronal guidance and mediate venal/arterial separation. Ephb4 provides survival advantage to squamous cell carcinoma of the head and neck. It has tumor suppressor activities and that regulation of cell proliferation, extracellular matrix remodeling, and invasive potential are important mechanisms of tumor suppression. Recombinant mouse Ephb4, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

EPH receptor B4, Ephrin type-B receptor 4, Developmental kinase 2, mDK-2, Hepatoma transmembrane kinase, Tyrosine kinase MYK-1, Htk, Mdk2, Tyro11

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 85% by SDS-PAGE

Molecular Weight

58.7 kDa (532aa)

Additionnal Information

EphB4, Ephrin type-B receptor 4 isoform b, Eph receptor B4, AI042935, Htk, MDK2, Myk1, Tyro11, Ephb4, EPHB4_HUMAN, Ephrin receptor, EphB4, Ephrin type-B receptor 4, Hepatoma Transmembrane Kinase, HTK, MYK 1, MYK1, TYRO 11, TYRO11, Tyrosine-protein kinase receptor HTK, Tyrosine-protein kinase TYRO11, ATGP3415-10 µg, ATGP3415-20 µg, ATGP3415-50 µg, ATGP3415-100 µg, ATGP3415-250 µg, ATGP3415-500 µg, ATGP3415-1 mg, ATGP3415-10, ATGP3415-20, ATGP3415-50, ATGP3415-100, ATGP3415-250, ATGP3415-500, ATGP3415-1

References & Citations

Xiao Z. et al., (2012) Cancer Biol Ther. 13:630-637.; ; Masood R. et al., (2006) Int J Cancer. 119:1236-1248.; ; Dopeso H. et al., (2009) Cancer Res. 69:7430-7438.