Recombinant mouse Carnosine Dipeptidase 1/CNDP1 protein
Cndp1, as known as beta-Ala-His dipeptidase, is a member of the M20 metalloprotease family. In human, this protein is secreted from the liver into the serum. In other mammals, including rodents, it is expressed exclusively within the kidney and lacks a signal peptide. Also, it is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine, and is identified as human carnosinase expressed in the brain. Recombinant mouse Cndp1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosine dipeptidase 1, CN1, Carnosinase 1
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
56.1 kDa (500aa)
Additionnal Information
References & Citations
Janssen B., et al, (2005) Diabetes. 54:2320-2327.; ; Teufel M., et al, (2003) J. Biol. Chem. 278:6521-6531.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_803233
Uniprot Accession Number
Q8BUG2
Species
Mouse
N Terminal Sequence
Met1
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