Recombinant human Chitinase 3-like 1/CHI3L1 protein

CHI3L1, also known as chitinase-3-like protein 1, is a member of the glycosyl hydrolase 18 family. This protein can bind heparins, probably as heparin sulfate. It has been found to enhance cell adhesion and promote cell signaling, proliferation and tumor angiogenesis. Elevated serum CHI3L1 levels occur in some conditions characterized by inflammation and connective tissue remodeling such as arthritis, chronic obstructive pulmonary disease, diabetes, cardiovascular disease, inflammatory bowel disease, and liver cirrhosis. Recombinant human CHI3L1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Chitinase 3-like 1, cartilage glycoprotein-39, CGP-39; GP-39; hCGP-39, YKL40, YKL-40, YK-40, 39 kDa synovial protein, ASRT7

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

41.4 kDa (370aa)

Additionnal Information

Chitinase3-like1, Chitinase-3-like protein 1 , CHI3L1, ASRT7, CGP-39, GP-39, GP39, HC-gp39, hCGP-39, HCGP-3P, YKL-40, YYL-40, 39 kDa synovial protein, ASRT7, Cartilage glycoprotein 39CGP-39, CGP39, CH3L1_HUMAN, CHI3L1, chitinasechitinase 3 like 1, chitinase 3 like 1 (cartilage glycoprotein 39), Chitinase 3 like protein 1 precursorChitinase-3-like protein 1, Chondrocyte protein YKL40GP 39, GP-39, GP39, HC gp39, HCGP 3P, hCGP-39HCgp39, YKL 40, YKL-40, YKL40, YYL 40, ATGP3405-10 µg, ATGP3405-20 µg, ATGP3405-50 µg, ATGP3405-100 µg, ATGP3405-250 µg, ATGP3405-500 µg, ATGP3405-1 mg, ATGP3405-10, ATGP3405-20, ATGP3405-50, ATGP3405-100, ATGP3405-250, ATGP3405-500, ATGP3405-1

References & Citations

Hakala BE., et al. (1993) J Biol Chem 268:25803-25810.; ; Eurich K., et al. (2009) World J Gastroenterol. 15:5249-5259.;

Other References

Suzuki H, et al. YKL-40 Promotes Proliferation of Cutaneous T-Cell Lymphoma Tumor Cells through Extracellular Signal-Regulated Kinase Pathways. (J Invest Dermatol. 2020) {https://pubmed.ncbi.nlm.nih.gov/31622598/}