Recombinant human TLR2 protein
TLR2, as known as toll-like receptor 2, belongs to the toll-like receptor (TLR) family. Human TLR family includes the members that activate the innate immune response via an ability to recognize molecular structures found in a variety of microbial pathogens. Specially, this protein is highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. It functions as part of a heterodimeric complex with either TLR1 or TLR6, and possibly other co-receptors. Recombinant human TLR2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
65.2 kDa (576aa)
Additionnal Information
References & Citations
Liu Y., et al. (2015) Eur. J. Immunol. 45:2683-2693.; ; Murphy M., et al. (2015) J. Biol. Chem. 290:19218-19232.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_003255
Uniprot Accession Number
O60603
Species
Human
N Terminal Sequence
Lys19
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