Recombinant human Pepsinogen C/PGC protein
PGC, also known as gastricsin, is an aspartic proteinase that belongs to the peptidase family A1. It is synthesized in the gastric mucosa as inactive precursors. It contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. Serum levels of PGC are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Recombinant human PGC, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques
Product Specifications
Product Name Alternative
Gastricsin, PGC, PEPC, PGII, Gastricsin, PEPC_HUMAN, pepsin C, Pepsinogen C, pepsinogen group II, PGII, preprogastricsin, Progastricsin
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
41.6 kDa (380aa)
Additionnal Information
References & Citations
Richter C., et al. (1998) Biochem J. 335:481-490.; ; Westerveld BD., et al. (1987) Gastroenterology. 93:774-778.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_002621
Uniprot Accession Number
P20142
Species
Human
N Terminal Sequence
Ala17
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