Recombinant human HVEM/TNFRSF14 protein

TNFRSF14, as known as tumor necrosis factor receptor superfamily member 14 isoform 1, is a type 1 membrane protein belonging to the TNF/NGF receptor superfamily. Expression of this protein has been detected in peripheral blood T cells, B cells, monocytes and in various tissue enriched in lymphoid cells. Binding of herpes simplex virus (HSV) viral envelope glycoprotein D to this receptor protein has been shown to be part of HSV entry mechanism, and from which its name derived. Recombinant human TNFRSF14, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, Tumor necrosis factor receptor-like 2, TR2, CD270, HVEM, ATAR, LIGHTR

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

44.6 kDa (406aa)

Additionnal Information

HVEM, TNFRSF14, Tumor necrosis factor receptor superfamily member 14 isoform 1, TNFRSF14, ATAR, CD270, HVEA, HVEM, LIGHTR, TR2, HVEML, CD40 like protein precursor, Herpes virus entry mediator A, Herpesvirus entry mediatorHerpesvirus entry mediator A, Herpesvirus entry mediator ligand, HveA, HVEM L, LIGHT, LIGHTRTNFRSF14, TNFSF 14, TNR14_HUMANTR2, Tumor necrosis factor receptor like gene2Tumor necrosis factor receptor superfamily member 14, Tumor necrosis factor receptor superfamily member 14 precursor, Tumor necrosis factor receptor-like 2, ATGP3379-10 µg, ATGP3379-20 µg, ATGP3379-50 µg, ATGP3379-100 µg, ATGP3379-250 µg, ATGP3379-500 µg, ATGP3379-1 mg, ATGP3379-10, ATGP3379-20, ATGP3379-50, ATGP3379-100, ATGP3379-250, ATGP3379-500, ATGP3379-1

References & Citations

Inoue T., et al. (2015) Anticancer Res. 35:1361-1367.; ; Steinberg MW., et al. (2011) Immunol. Rev. 244:169-187.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_003811

Uniprot Accession Number

Q92956

Species

Human

N Terminal Sequence

Ala

AA Sequence

LPSCKED EYPVGSECCP KCSPGYRVKE ACGELTGTVC EPCPPGTYIA HLNGLSKCLQ CQMCDPAMGL RASRNCSRTE NAVCGCSPGH FCIVQDGDHC AACRAYATSS PGQRVQKGGT ESQDTLCQNC PPGTFSPNGT LEECQHQTKC SWLVTKAGAG TSSSHWV