Recombinant human Kallikrein 7/KLK7 protein
KLK7, as known as kallikrein-7 isoform 2, is a secreted protein which belongs to the peptidase S1 family and kallikrein subfamily. Members of the kallikrein family are involved in various malignancies such as prostate (PSA, KLK2, KLK15), ovarian (KLK4, KLK5, KLK6, KLK8, KLK10), and breast cancer (KLK10, KLK13, LKL14) . This protein is expressed in the skin, a major physiological function of KLK7 is to regulate the desquamation process through proteolysis of the intercellular adhesive structure between corneocytes. Recombinant human KLK7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Stratum corneum chymotryptic enzyme, Serine protease 6, SCCE, PRSS6, KLK7, Kallikrein-7 isoform 2, Kallikrein-7, Kallikrein related peptidase 7, HK7
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
20.9 kDa (190aa)
Additionnal Information
References & Citations
Yu Y., et al. (2015) J. Biol. Chem. 290:17762-17775.; ; Tamir A., et al. (2014) J. Ovarian. Res. 7:109-124.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001193982
Uniprot Accession Number
P49862
Species
Human
N Terminal Sequence
Ala
AA Sequence
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