Recombinant mouse Testican 3/SPOCK3 protein
Spock3, also known as testican-3, is a nervous system-expressed heparan sulfate proteoglycan belonging to a subgroup of the BM-40/SPARC/osteonectin family, the role of which in brain development is unclear. It inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. It is mostly confined to the developmental stage of the brain. Recombinant mouse Spock3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Testican-3, Spock3, 2900045C01Rik, AI428471, mKIAA4039
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
47.9 kDa (423aa)
Additionnal Information
References & Citations
Hartmann U., et al. (2013) J Neurochem. 125:399-409.; ; Yamamoto A., et al. (2014) Dev Neurosci. 36:381-395.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001239549
Uniprot Accession Number
Q8BKV0
Species
Mouse
N Terminal Sequence
Ala22
AA Sequence
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