Recombinant human Integrin beta 2/CD18 protein
ITGB2, also known as integrin beta-2, is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It may belong to an extended family of cell surface molecules including the fibronectin binding protein. Also It is a complement receptor type 3 (CR3) . It triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Recombinant human ITGB2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
ITGB2, Cell surface adhesion glycoproteins LFA-1, CR3, p150,95 subunit beta, Complement receptor C3 subunit beta, MFI7, MAC-1
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Molecular Weight
75.9 kDa (686aa)
Additionnal Information
References & Citations
Law SK., et al. (1987) EMBO J. 6:915-919.; ; Xu J., et al. (2008) Nat Immunol. 9:880-886.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_000202.2
Uniprot Accession Number
P05107
Species
Human
N Terminal Sequence
Gln23
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