Recombinant human CD30 Ligand/TNFSF8 protein
TNFSF8, also known as tumor necrosis factor ligand superfamily member 8, is a type II membrane protein belonging to the TNF superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30/TNFRSF8 ligation by TNFSF8 mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. Recombinant human TNFSF8, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Human CD30 Ligand/TNFSF8 is coated at 2 µg/mL (100 ul/well) can bind Human CD30/TNFRSF8 (CAT# ATGP3389) in a Functional ELISA assay.
Product Name Alternative
Tumor necrosis factor ligand superfamily member 8, TNFSF8, CD153, CD30L, CD30LG, TNLG3A
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Bioactivity
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 85% by SDS-PAGE
Bioactivity
Measured by its binding ability in a functional ELISA with Human CD30/TNFRSF8 (CAT# ATGP3389)
Molecular Weight
20.7 kDa (181aa)
Additionnal Information
References & Citations
Duckett CS., et al. (1997) Mol. Cell. Biol. 17:1535-1542.; ; Chiarle R., et al. (1999) J. Immunol. 163:194-205.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_001235
Uniprot Accession Number
P32971
Species
Human
N Terminal Sequence
Ala
AA Sequence
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