Recombinant mouse Glyoxalase I protein
Glo1, also known as lactoylglutathione lyase, is a member of the glyoxalase l family. It plays a critical role in the detoxification of 2-oxoaldehydes, such as methylglyoxal. It involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. It was identified as a protein marker, which is consistently expressed to a higher extent in LAB-M than in HAB-M mice in several brain areas. Recombinant mouse Glo1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Specifications
Product Name Alternative
Glyoxalase 1, Lactoylglutathione lyase, 0610009E22Rik, 1110008E19Rik, 2510049H23Rik, AW550643, Glo-1, Glo-1r, Glo-1s, Glo1-r, Glo1-s, GLY1, Qglo
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
Enzyme Activity, SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Bioactivity
Molecular Weight
21.8 kDa (192aa)
Additionnal Information
References & Citations
Kawatani M., et al. (2008) Proc Natl Acad Sci U S A. 105:11691-11696.; ; Kromer SA., et al. (2005) J Neurosci. 25:4375-4384.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_079650
Uniprot Accession Number
Q9CPU0
Species
Mouse
N Terminal Sequence
Met1
AA Sequence
Frequently Asked Questions
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