Recombinant human SR-AI/MSR1 protein
MSR1, as known as macrophage scavenger receptor types I and II isoform type 1, is single-pass type II membrane protein. Scavenger receptors are a group of membrane receptors that recognize and internalize modified low density lipoproteins (LDLs) and participate in the removal of many foreign substances and waste materials in the living body. Scavenger receptors are categorized into three classes, and class A mainly expressed in macrophage includes three isoforms derived by alternative splicing. This protein, has been suggested to play important roles in macrophage growth, cell adhesion, osteoclast differentiation, and as well as intracellular signaling. Recombinant human MSR1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Macrophage scavenger receptor types I and II isoform type 1, CD204, phSR1, phSR2, SCARA1, SRA, SR-A
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
42.4 kDa (384aa)
Additionnal Information
References & Citations
Dansako H., et al. (2013) PLoS Pathog. 9:E1003345.; ; Shigeoka M., et al. (2013) Cancer Sci. 104:1112-1119.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_619729
Uniprot Accession Number
P21757
Species
Human
N Terminal Sequence
Ala
AA Sequence
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