Recombinant human SR-AI/MSR1 protein

MSR1, as known as macrophage scavenger receptor types I and II isoform type 1, is single-pass type II membrane protein. Scavenger receptors are a group of membrane receptors that recognize and internalize modified low density lipoproteins (LDLs) and participate in the removal of many foreign substances and waste materials in the living body. Scavenger receptors are categorized into three classes, and class A mainly expressed in macrophage includes three isoforms derived by alternative splicing. This protein, has been suggested to play important roles in macrophage growth, cell adhesion, osteoclast differentiation, and as well as intracellular signaling. Recombinant human MSR1, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Macrophage scavenger receptor types I and II isoform type 1, CD204, phSR1, phSR2, SCARA1, SRA, SR-A

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

42.4 kDa (384aa)

Additionnal Information

SR-AI, MSR1, Macrophage scavenger receptor types I and II isoform type 1, CD204, phSR1, phSR2, SCARA1, SRA, SR-A, ATGP3333-10 µg, ATGP3333-20 µg, ATGP3333-50 µg, ATGP3333-100 µg, ATGP3333-250 µg, ATGP3333-500 µg, ATGP3333-1 mg, ATGP3333-10, ATGP3333-20, ATGP3333-50, ATGP3333-100, ATGP3333-250, ATGP3333-500, ATGP3333-1

References & Citations

Dansako H., et al. (2013) PLoS Pathog. 9:E1003345.; ; Shigeoka M., et al. (2013) Cancer Sci. 104:1112-1119.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_619729

Uniprot Accession Number

P21757

Species

Human

N Terminal Sequence

Ala

AA Sequence

KWETKNC SVSSTNANDI TQSLTGKGND SEEEMRFQEV FMEHMSNMEK RIQHILDMEA NLMDTEHFQN FSMTTDQRFN DILLQLSTLF SSVQGHGNAI DEISKSLISL NTTLLDLQLN IENLNGKIQE NTFKQQEEIS KLEERVYNVS AEIMAMKEEQ VHLEQEIKGE VKVLNNITND LRLKDWEHSQ TLRNITLIQG PPGPPGEKGD RGPTGESGPR GFPGPIGPPG LKGDRGAIGF PGSRGLPGYA GRPGNSGPKG QKGEKGSGNT LTPFTKVRLV GGSGPHEGRV EILHSGQWGT ICDDRWEVRV GQVVCRSLGY PGVQAVHKAA HFGQGTGPIW LNEVFCFGRE SSIEECKIRQ WGTRACSHSE DAGVTCTL