Recombinant human TPST2 protein
TPST2, also known as protein-tyrosine sulfotransferase 2, is the enzyme that catalyzes the sulfation reaction of protein tyrosines, a post-translational modification of proteins. This protein is a type II integral membrane protein found in the Golgi body. Compared to TPST1, TPST2 has similar tissue distribution and overlapping substrate specificity. In contrast to TPST1-/- males with normal fertility in mice, TPST2-/- males are infertile due to severe defects in sperm motility. Recombinant human TPST2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Protein-tyrosine sulfotransferase 2, TANGO13B
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
40.4 kDa (361aa)
Additionnal Information
References & Citations
Danan LM., et al. (2008) . J Am Soc Mass Spectrom. 19 (10) :1459-1466.; ; Kehoe J.W. and Bertozzi C.R. (2000) Chemistry & Biology. 7:57-61.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_001008566.1
Uniprot Accession Number
O60704
Species
Human
N Terminal Sequence
Ala
AA Sequence
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