Recombinant human GITR/TNFRSF18 protein

TNFRSF18, also known as tumor necrosis factor receptor superfamily member 18 isoform 1, is receptor for TNFSF18. It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. TNFRSF18 mediated NF-kappa-B activation via the TRAF2/NIK pathway. Also, this protein reciprocally stimulated and activate intracellular signals regulating immune functions. In particular, GITR-driven T-cell co-stimulation was found to be the main mechanism by which the GITRL-GITR system contributes to tumor rejection and the development of autoimmune/inflammatory diseases. Recombinant human TNFRSF18, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Tumor necrosis factor receptor superfamily member 18, Activation-inducible TNFR family receptor, Glucocorticoid-induced TNFR-related protein, CD357, AITR, GITR

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

41.6 kDa (376aa)

Additionnal Information

GITR, TNFRSF18, Tumor necrosis factor receptor superfamily member 18 isoform 1, AITR, CD357, GITR, GITR-D, ATGP3319-10 µg, ATGP3319-20 µg, ATGP3319-50 µg, ATGP3319-100 µg, ATGP3319-250 µg, ATGP3319-500 µg, ATGP3319-1 mg, ATGP3319-10, ATGP3319-20, ATGP3319-50, ATGP3319-100, ATGP3319-250, ATGP3319-500, ATGP3319-1

References & Citations

Lacal PM., et al. (2013) J. Pharmacol. Exp. Ther. 347:164-172.; ; Xufre C., et al. (2013) Int. Immunol. 25:563-574.; ; Shimizu J., et al. (2002) Nat. Immunol. 3:135-142.