Recombinant human RANK/TNFRSF11A protein

TNFRSF11A, also known as tumor necrosis factor receptor superfamily member 11A, is a member of the tumor necrosis factor receptor family. TNFRSF11A is widely expressed with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland and dendritic cells. In activated human peripheral blood T lymphocytes, TNFRSF11A expression is induced by IL4 and TGF-b. Recombinant human TNFRSF11A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

TNF receptor superfamily member 11a, Osteoclast differentiation factor receptor, Receptor activator of NF-KB, Familial expansile osteolysis, TRANCE receptor, RANK, CD265, FEO, ODFR, TRANCE-R

Expression System

Baculovirus

Antigen Species

Human

Tag

HIgG-His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 90% by SDS-PAGE

Molecular Weight

47.6 kDa (427aa)

Additionnal Information

RANK, TNFRSF11A, TNFRSF11A, CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER, ATGP3304-10 µg, ATGP3304-20 µg, ATGP3304-50 µg, ATGP3304-100 µg, ATGP3304-250 µg, ATGP3304-500 µg, ATGP3304-1 mg, ATGP3304-10, ATGP3304-20, ATGP3304-50, ATGP3304-100, ATGP3304-250, ATGP3304-500, ATGP3304-1

References & Citations

Anderson DM., et al. (1997) Nature 390:175-179.; ; Guerrini MM., et al. (2008) Am. J. Hum. Genet. 83:64-76.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_003830

Uniprot Accession Number

Q9Y6Q6

Species

Human

N Terminal Sequence

Ala

AA Sequence

LQIAPPC TSEKHYEHLG RCCNKCEPGK YMSSKCTTTS DSVCLPCGPD EYLDSWNEED KCLLHKVCDT GKALVAVVAG NSTTPRRCAC TAGYHWSQDC ECCRRNTECA PGLGAQHPLQ LNKDTVCKPC LAGYFSDAFS STDKCRPWTN CTFLGKRVEH HGTEKSDAVC SSSLPARKPP NEPHVYLP