Recombinant mouse ErbB3/Her3 protein
ERBB3, also known as receptor tyrosine-protein kinase erbB-3, is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This protein has been shown to implicate in numerous cancers, including prostate, bladder, and breast tumors. Also, it is found in epithelial cell layers of gastrointestinal, reproductive, urinary, endocrine and nervous systems, skin and muscle. ERBB3 has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. Recombinant mouse ERBB3, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
ERBB3, C76256, Erbb-3, Erbb3r, Her3
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 90% by SDS-PAGE
Molecular Weight
69.5 kDa (630aa)
Additionnal Information
References & Citations
Hao J., et al. (2014) Biochem. J. 458:335-341.; ; Kwon HS., et al. (2013) J. Biol. Chem. 288:26357-26371.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_034283
Uniprot Accession Number
Q61526
Species
Mouse
N Terminal Sequence
Ser20
AA Sequence
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