Recombinant human TIMP-2 protein

TIMP2, also known as metalloproteinase inhibitor 2, belongs to the tissue inhibitors of metalloproteinases family. The TIMP family inhibit most MMPs by forming non-covalent binary complex. TIMP2 plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Recombinant human TIMP2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

TIMP2, CSC-21K, DDC8

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

22.5 kDa (200aa)

Additionnal Information

TIMP2, TIMP2, CSC-21K, DDC8, ATGP3301-10 µg, ATGP3301-20 µg, ATGP3301-50 µg, ATGP3301-100 µg, ATGP3301-250 µg, ATGP3301-500 µg, ATGP3301-1 mg, ATGP3301-10, ATGP3301-20, ATGP3301-50, ATGP3301-100, ATGP3301-250, ATGP3301-500, ATGP3301-1

References & Citations

Stetler-Stevenson WG and Seo DW. (2005) Trends Mol Med 11:97-103.; ; Seo DW., et al. (2003) Cell 114:171-180.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Angiogenesis

NCBI Accession Number

NP_003246

Uniprot Accession Number

P16035

Species

Human

N Terminal Sequence

Cys27

AA Sequence

CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDPHHHHHH