Recombinant mouse Dectin-1/CLEC7A protein

CLEC7A, also known as C-type lectin domain family 7 member A 1, that functions as in the innate immune response to fungal pathogens. It is expressed on monocytes, macrophages, and neutrophils, and on some populations of dendritic cells and T cells. It is upregulated on macrophages by GM-CSF, IL-4, or IL-13 and downregulated by dexamethasone, IL-10, or LPS. Recombinant mouse CLEC7A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

C-type lectin domain family 7, member a, beta-glucan receptor, beta-GR, BGR, Clecsf12, Dectin-1

Expression System

Baculovirus

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

21kDa (183aa)

Additionnal Information

Dectin1, CLEC7A, CLEC7A, beta-GR, BGR, Clecsf12, ATGP3282-10 µg, ATGP3282-20 µg, ATGP3282-50 µg, ATGP3282-100 µg, ATGP3282-250 µg, ATGP3282-500 µg, ATGP3282-1 mg, ATGP3282-10, ATGP3282-20, ATGP3282-50, ATGP3282-100, ATGP3282-250, ATGP3282-500, ATGP3282-1

References & Citations

Yadav M., et al. (2006) Blood 108:3168-3175.; ; Willment J. A., et al. (2003) J. Immuol. 171:4569-4573.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

AAF72710.1

Uniprot Accession Number

Q6QLQ4

Species

Mouse

N Terminal Sequence

Ala

AA Sequence

RHNSGRN PEEKDNFLSR NKENHKPTES SLDEKVAPSK ASQTTGGFSQ SCLPNWIMHG KSCYLFSFSG NSWYGSKRHC SQLGAHLLKI DNSKEFEFIE SQTSSHRINA FWIGLSRNQS EGPWFWEDGS AFFPNSFQVR NTVPQESLLH NCVWIHGSEV YNQICNTSSY SICEKEL