Recombinant mouse Dectin-1/CLEC7A protein
CLEC7A, also known as C-type lectin domain family 7 member A 1, that functions as in the innate immune response to fungal pathogens. It is expressed on monocytes, macrophages, and neutrophils, and on some populations of dendritic cells and T cells. It is upregulated on macrophages by GM-CSF, IL-4, or IL-13 and downregulated by dexamethasone, IL-10, or LPS. Recombinant mouse CLEC7A, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
C-type lectin domain family 7, member a, beta-glucan receptor, beta-GR, BGR, Clecsf12, Dectin-1
Expression System
Baculovirus
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
21kDa (183aa)
Additionnal Information
References & Citations
Yadav M., et al. (2006) Blood 108:3168-3175.; ; Willment J. A., et al. (2003) J. Immuol. 171:4569-4573.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
AAF72710.1
Uniprot Accession Number
Q6QLQ4
Species
Mouse
N Terminal Sequence
Ala
AA Sequence
Frequently Asked Questions
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