Recombinant human GP130/IL6ST protein

IL6ST, also known as interleukin6 signal transducer, belongs to class 1 cytokine receptor family. Binding of IL-6 (IL-11) to either the membrane-anchored or soluble IL-6R (IL-11R) initiates the association of IL-6 R (IL-11 R) with IL6ST when then undergoes homo-dimerization and signal transduction. Recombinant human IL6ST, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Interleukin 6 cytokine family signal transducer, gp130, oncostatin M receptor, GP130, CD130, sGP130, membrane glycoprotein 130, Interleukin-6 receptor subunit beta, IL-6RB

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.25 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

68.9 kDa (605aa)

Additionnal Information

IL6ST, IL6ST, CD130, CDw130, GP130, GP130-RAPS, IL6R-beta, ATGP3271-10 µg, ATGP3271-20 µg, ATGP3271-50 µg, ATGP3271-100 µg, ATGP3271-250 µg, ATGP3271-500 µg, ATGP3271-1 mg, ATGP3271-10, ATGP3271-20, ATGP3271-50, ATGP3271-100, ATGP3271-250, ATGP3271-500, ATGP3271-1

References & Citations

Narazaki M., et al. (1993) Blood 82:1120-1126.; ; Taga T. and T. Kishimoto (1997) Annu. Rev. Immunol. 15:797-819.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Apoptosis

NCBI Accession Number

AAI17405

Uniprot Accession Number

Q17RA0

Species

Human

AA Sequence

ELLDPCGYIS PESPVVQLHS NFTAVCVLKE KCMDYFHVNA NYIVWKTNHF TIPKEQYTII NRTASSVTFT DIASLNIQLT CNILTFGQLE QNVYGITIIS GLPPEKPKNL SCIVNEGKKM RCEWDRGRET HLETNFTLKS EWATHKFADC KAKRDTPTSC TVDYSTVYFV NIEVWVEAEN ALGKVTSDHI NFDPVYKVKP NPPHNLSVIN SEELSSILKL TWTNPSIKSV IILKYNIQYR TKDASTWSQI PPEDTASTRS SFTVQDLKPF TEYVFRIRCM KEDGKGYWSD WSEEASGITY EDRPSKAPSF WYKIDPSHTQ GYRTVQLVWK TLPPFEANGK ILDYEVTLTR WKSHLQNYTV NATKLTVNLT NDRYVATLTV RNLVGKSDAA VLTIPACDFQ ATHPVMDLKA FPKDNMLWVE WTTPRESVKK YILEWCVLSD KAPCITDWQQ EDGTVHRTYL RGNLAESKCY LITVTPVYAD GPGSPESIKA YLKQAPPSKG PTVRTKKVGK NEAVLEWDQL PVDVQNGFIR NYTIFYRTII GNETAVNVDS SHTEYTLSSL TSDTLYMVRM AAYTDEGGKD GPEFTFTTPK FAQGEIELEH HHHHH