Recombinant human BCMA/TNFRSF17 protein
TNFRSF17, also known as tumor necrosis factor receptor superfamily member 17, is a member of the TNF receptor superfamily. It is a receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL and promotes B-cell survival and plays a role in the regulation of humoral immunity. It activates NF-kappa-B and JNK. Recombinant human TNFRSF17, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Tumor necrosis factor receptor superfamily member 17, B-cell maturation protein
Expression System
Baculovirus
Antigen Species
Human
Tag
HIgG-His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
33.1Da (296aa)
Additionnal Information
References & Citations
Hatzoglou A., et al. (2000) J. Immunol. 165:1322-1330.; ; Gross J. A., et al. (2000) Nature 404:995-999.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_001183.2
Uniprot Accession Number
Q02223
Species
Human
AA Sequence
MLQMAGQ CSQNEYFDSL LHACIPCQLR CSSNTPPLTC QRYCNASVTN SVKGTNA
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