Recombinant human CRACC/SLAMF7 protein
SLAMF7, also known as SLAM family member 7, is a single-pass type 1 membrane protein and a member of the CS2 family of cell surface receptors. Isoform 1 of this protein mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. SLAMF7 can exert activating of inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. Recombinant human SLAMF7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
SLAMF7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CRACC, CS1, CD319, Membrane protein FOAP-12, Novel Ly9, Protein 19A
Expression System
Baculovirus
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by absorbance at 280 nm)
Endotoxin
< 1 EU per 1ug of protein (determined by LAL method)
Purity
> 95% by SDS-PAGE
Molecular Weight
23.4 kDa (212aa)
Additionnal Information
References & Citations
Kim JR et al., (2013) Inflamm. Res. 62 (8) :765-772.; ; Kramer B et al., (2013) Infect. Immun. 81 (3) :690-696.
Other References
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
Scientific Category
Immunology
NCBI Accession Number
NP_067004
Uniprot Accession Number
Q9NQ25
Species
Human
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