Recombinant human CRACC/SLAMF7 protein

SLAMF7, also known as SLAM family member 7, is a single-pass type 1 membrane protein and a member of the CS2 family of cell surface receptors. Isoform 1 of this protein mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. SLAMF7 can exert activating of inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins. Recombinant human SLAMF7, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

SLAMF7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CRACC, CS1, CD319, Membrane protein FOAP-12, Novel Ly9, Protein 19A

Expression System

Baculovirus

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by absorbance at 280 nm)

Endotoxin

< 1 EU per 1ug of protein (determined by LAL method)

Purity

> 95% by SDS-PAGE

Molecular Weight

23.4 kDa (212aa)

Additionnal Information

CRACSLAMF7, SLAMF7, CD2 subset 1, CD2-like receptor-activating cytotoxic cells, CRACC, CS1, CD319, ATGP3258-10 µg, ATGP3258-20 µg, ATGP3258-50 µg, ATGP3258-100 µg, ATGP3258-250 µg, ATGP3258-500 µg, ATGP3258-1 mg, ATGP3258-10, ATGP3258-20, ATGP3258-50, ATGP3258-100, ATGP3258-250, ATGP3258-500, ATGP3258-1

References & Citations

Kim JR et al., (2013) Inflamm. Res. 62 (8) :765-772.; ; Kramer B et al., (2013) Infect. Immun. 81 (3) :690-696.

Other References

Kikuchi J, et al. Soluble SLAMF7 promotes the growth of myeloma cells via homophilic interaction with surface SLAMF7. (Leukemia. 2020) {https://pubmed.ncbi.nlm.nih.gov/31358854/}