Recombinant mouse MESDC2 protein

MESDC2 also known as LDLR chaperone MESD. This protein is specialized chaperone for low-density lipoprotein receptor-related protein 5 and LRP6. MESDC2 binds to mature LRP6 on the cell surface and blocks the binding of Wnt antagonist Dickkopf-1 to LRP6. Furthermore, MESDC2 plays an essential role in NMJ formation by promoting Lrp4 maturation. Recombinant mouse MESDC2, fused to His-tag at N-terminus was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

2210015O11Rik, AW537813, mesd, mKIAA0081, msd

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE

Concentration

1 mg/mL (determined by absorbance at 280 nm)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.4 kDa (218aa)

Additionnal Information

MESDC2, 2210015O11Rik, AW537813, mesd, mKIAA0081, msd, ATGP3257-10 µg, ATGP3257-20 µg, ATGP3257-50 µg, ATGP3257-100 µg, ATGP3257-250 µg, ATGP3257-500 µg, ATGP3257-1 mg, ATGP3257-10, ATGP3257-20, ATGP3257-50, ATGP3257-100, ATGP3257-250, ATGP3257-500, ATGP3257-1

References & Citations

Lu W., et al. (2010) Biochemistry. 49 (22) : 4635-43.; ; Hoshi T., et al. (2013) FEBS Lett. 587 (23) : 3749-54.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol

Scientific Category

Signal Transduction

NCBI Accession Number

NP_075892

Uniprot Accession Number

Q9ERE7

Species

Mouse

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSADTPGEA TPPPRKKKDI RDYNDADMAR LLEQWEKDDD IEEGDLPEHK RPSAPIDFSK LDPGKPESIL KMTKKGKTLM MFVTVSGNPT EKETEEITSL WQGSLFNANY DVQRFIVGSD RAIFMLRDGS YAWEIKDFLV SQDRCAEVTL EGQMYPGKGG GSKEKNKTKP EKAKKKEGDP KPRASKEDNR AGSRREDL